Ligand requirements for involvement of PKCε in synergistic analgesic interactions between spinal μ and δ opioid receptors
نویسندگان
چکیده
منابع مشابه
Spinal interaction between μ and δ opioid receptors in naive and morphine-tolerant rats
Background The role of δ opioid receptors in opioid antinociception and tolerance development is still unclear. In the spinal cord of morphine-tolerant mice δ receptor ligands given intrathecally (i.t.) differently influenced the antinociceptive effect of the μ agonist D-Ala2-methyl-glycinol (DAMGO). The δ1 agonist D-Pen2,5-enkephalin (DPDPE) inhibited, the δ2 agonist deltorphin II did not alte...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 2014
ISSN: 0007-1188
DOI: 10.1111/bph.12774